Leading-edge integrative Treatment for MTHFR genetic mutation

The MTHFR mutation has multiple presentations, significant variances in the specific symptoms and degree of symptoms experienced by different patients.  Accordingly, treatment has to be customized for each patient as there is no one single treatment protocol for all patients.  Immediately below, we present the conditions and symptoms caused or worsened by the MTHFR mutation.  Below this initial table, we present a high-level overview our approach and treatment protocol. Again, we caution patients from attempting to use this protocol without physician supervision.

The foundation of our approach to treating this mutation is our Comprehensive Initial Assessment.  This assessment, which includes 1 ½ hours with one of our physicians provides the basis for establishing the appropriate treatment protocol, taking into consideration the number and degree of your symptoms as well as other health conditions that you have that may or may not be related.


Conditions and symptoms caused or made worse by MTHFR mutation


Addictions: smoking, drugs, alcohol


Pulmonary embolisms

Depression in Post-Menopausal Women


Fibromyalgia and Chronic Fatigue Syndrome

Chemical Sensitivity


Irritable Bowel Syndrome



Colorectal Adenoma

Idiopathic male infertility

Blood clots

Rectal cancer

Deficits in childhood cognitive development

Gastric Cancer

Migraines with aura


High homocysteine

Post-menopausal breast cancer


Oral Clefts

Type 1 Diabetes



Potential drug toxicities: methotrexate, anti-epileptics

Increased bone fracture risk in post-menopausal women

Multiple Sclerosis

Essential Hypertension

Prostate Cancer

Myocardial Infarction (Heart Attack)

Methotrexate Toxicity

Nitrous Oxide Toxicity

Heart Murmurs


Shortness of Breath

Bladder Cancer



Treatment Protocol

Our treatment protocol uses a functional medicine approach.  This is why it begins with our comprehensive initial assessment.  We seek to find root causes to your health issues since many issues you present with are not likely directly caused by the MTHFR mutation.  By using a functional medicine approach, we understand that imbalances in one part of the body may manifest in other systems.  So we avoid the specialist approach that focuses on the disease from a single system view and view the body as a single system of systems.  Using functional medicine as our guide, our treatment protocol is described below.

 1.      Testing.  Advanced testing is the key to our customized treatment programs.  Following are the tests that we used in treating the MTHFR mutation.

a.       Comprehensive lab panel

b.      MTHFR Genotype test

c.       Food sensitivity test

d.      CIMT (due to increased cardiovascular risk)

2.      Dietary Guidelines.  Following are the general dietary guidelines.  The specific guidelines are customized for each patient based on the results of food sensitivity testing.

a.       Eliminate/reduce dairy

b.      Eliminate/reduce gluten

c.       Drink a green smoothie daily

d.      Limit intake of folic acid

e.      Limit intake of processed foods

f.        Avoid antacids

3.      Lifestyle Guidance.  Depending on age , lab results and degree of symptoms, lifestyle adjustments may be required for symptomatic improvement in some patients.  Below are the areas of focus for lifestyle guidance.

a.       Balance hormones with Biodentical Hormone Replacement Therapy where indicated

b.      Eliminate carpeting from the home

c.       Filter chlorine from all water in the household

d.      Cook with electric stove; avoid using gas stoves

4.      Nutritional Supplementation.  This is a cornerstone for many of our programs but is especially important for patients with the MTHFR mutation.  IV Vitamin Therapy provides immediate relief to many patients and oral supplementation helps to sustain these benefits.  Below are the critical areas of nutritional supplementation for most patients.

a.       Broad spectrum IV Vitamin Therapy possibly including amino acids where indicated

b.      Comprehensive multivitamin (without folic acid)

c.       Metholated folate

d.      Glutathione

e.      Fish oil

f.        Nattokinase

g.       Vitamin C

h.      Vitamin D3

i.         Probiotics

Success Stories

Doctor's Note
Patient commenced with Health Assurance Progrm with an aggressive focus on weight loss and hormone balancing.
Patient Response
"So far I have lost 30#’s in 6 weeks and have the energy of a 40 year old. Am so thankful to be able to handle unpacking and shelving 6000 books. I am up and down stepladders and extension ladders with books in tow. The awful arthritis pain is there but the energy isn’t depleted from the pain like before and I keep going like this for hours."

LL - Winchester, VA